Juvenile idiopathic arthritis with uveitis.

Descriere Background: Uveitis is a potentially blinding complication of juvenile idiopathic arthritis JIA. Treatment remains a substantial challenge, even though the use of tumor necrosis factor TNF -α-antagonists has improved visual outcomes substantially.

ruperea vătămării umărului șoldul se crispa de durere

Among these agents, adalimumab has been recently approved for the treatment of non-infectious uveitis and is thus the first biologic disease-modifying anti-rheumatic drug bDMARD approved for JIA-associated uveitis. However, some patients do not respond sufficiently or lose response over time.

Lecture: Pediatric Uveitis

Recently golimumab, a fully humanized anti-TNF-α monoclonal antibody, demonstrated efficacy in a small case series, leading to uveitis inactivity in 4 of 7 patients Golimumab is approved for the treatment of polyarticular JIA. Hypothesis: Patients with JIA-associated uveitis failing treatment with adalimumab benefit from the treatment with golimumab.

All patients that have started golimumab from March are included in the study.

artrita articulațiilor mâinii artroza bilaterală a articulațiilor umărului

Primary failure to adalimumab was diagnosed in patients without change in the SUN score and an entry grade of 3 or higher or with worsening activity, defined as either a two-grade increase in inflammation or an increase to grade 4.

With bilateral disease, the eye with the higher grade of uveitis was analysed.

  • Cauze de dureri în articulații mici
  • Tratamentul articular cu artra
  • Articulațiile rănesc degetele
  • Arthrolon pl
  • Exercițiu de tratament cu artroză

Relapse of uveitis was defined as active inflammation after an inactivity for at least 3 months. Loss of response was defined as failure to improve under continued treatment with adalimumab despite intermitting intensifying concomitant therapy, such as local or systemic steroids.

inflamație pelvină tratamentul displaziei de șold tip 2 a

Golimumab treatment was administered in the standard dose of 50 mg sc every 4 weeks in patients with a weight of at least 40 kg. The outcome measures of uveitis include the reduction in grade of intraocular inflammation, the best-corrected visual acuity, eye soreness, redness of eyes, light sensitivity and the steroid sparing potential.

mușchii articulației genunchiului unei persoane rănite inflamația țesuturilor periarticulare ale articulațiilor mari

Response to treatment is classified as complete, partial or no response. Complete response constitute achieving inactive uveitis, defined as Patients receiving Golimumab were evaluated clinically and immunologically at regular intervals.

Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome.

At each visit the laboratory analysis included complete blood cell counts, levels of creatinine, hepatobiliary-injury biomarkers, juvenile idiopathic arthritis with uveitis C-reactive protein. Side effects were assessed by patient's reported history.

studii de boală articulară artroza de tratare a nămolului

Statistical analysis Continuous variables will be analyzed by Student's t-test or Mann-Whitney U test. Correlations will be analyzed by Spearman's rank correlation test. Binary variables were analyzed using Fisher's exact test.

tratamentul de unguente de umeri de lux cum să restaurați o articulație cu artroza

Statistical significance was defined as p Datele.